Implications of water environment policy for irrigated agriculture in Portugal

This research develops a bio-economic modelling framework for the assessment of agricultural and water policy change implications for irrigated agriculture. It aims to contribute towards the implementation of the Water Framework Directive within the European Union, particularly in regard to the principles of cost recovery of water services and water demand management for irrigation. The bio-economic framework combines local agro-ecological with socio-economic elements, allowing for the introduction of biophysical relationships of irrigated agricultural production into the appraisal of policy instruments. This framework is used to investigate the comparative performance of water management policy instruments for irrigation, including volumetric pricing, flat pricing, a two-part tariff and water allotments. Implications of these water policy instruments are assessed in combination with agricultural market and policy scenarios, which are used to define the economic background in which water policies will operate. This operational framework is designed within a microeconomic context at the farm level that takes into account crop yield-water relationships, the revealed economic behaviour of farmers, as well as structural productive patterns of representative agricultural systems in two case study areas in the south of Portugal. This integrated approach provides a comprehensive understanding of the implications of agricultural and water policies on irrigated agriculture within the European Union, unravels conflicts and identifies synergies between these policies. Simulation of water policy instruments produced substantial differences in performance across farming systems, enforcement levels, and agricultural policy and market settings. Results suggest that water pricing, on its own, is not necessarily the most effective means for achieving the WFD water demand management and cost recovery objectives, and proposes that a policy mix combining economic with regulatory elements may be best designed to pursue these objectives with fewer detrimental consequences. This study highlights that conflicts between CAP and the WFD may result in losses of efficiency, policy efficacy and losses of welfare, that could be minimised by integrating both policy measures and objectives, in a coherent and combined approach, exploring synergies and coordinating efforts to overcome sources of conflict

Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor

A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trelat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. This report describes a case of a patient with hypoinsulinemic hypoglycemia and Leser-Trelat sign associated with a malignant solitary fibrous tumor with IGF2 secretion. Both conditions have improved after tumor excision.Univ Fed Sao Paulo, Div Endocrinol, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Div Endocrinol, Escola Paulista Med, Sao Paulo, SP, BrazilWeb of Scienc

A systematic review of treatment of Painful Diabetic Neuropathy by Pain Phenotype versus treatment Based on Medical comorbidities

Background: Painful diabetic neuropathy (PDN) is a serious, polymorphic, and prevalent complication of diabetes mellitus. Most PDN treatment guidelines recommend a selection of drugs based on patient comorbidities. Despite the large numbers of medications available, most randomized clinical trials (RCTs) conducted so far have yielded unsatisfactory outcomes. Therefore, treatment may require a personalized approach based on pain phenotype or comorbidities. Methods: To evaluate whether or not a patient's pain phenotype or comorbidities can influence the response to a specific PDN treatment, we conducted a systematic review using two different approaches: pain phenotype and associated comorbidities-based treatment. Results: Out of 45 identified papers, 7 were thoroughly reviewed. We found four RCTs stratified according to pain phenotype with three main results: (1) paroxysmal pain had a better response to pregabalin(2) the preservation of thermal sensation or nociception anticipated a positive response to the topical treatment of painand, (3) after a failure to duloxetine (60 mg/day), the patients with evoked pain or severe deep pain had a better response to association of duloxetine/pregabalin while those with paresthesia/dysesthesia benefited from duloxetine monotherapy (120 mg/day). By contrast, the other three papers provided weak and even contradictory evidence about PDN treatment based on comorbidities. Conclusion: Although more studies are needed to provide an adequate recommendation for clinical practice, our systematic review has provided some evidence that PDN phenotyping may optimize clinical outcomes and could, in the future, lead to both less empirical medicine and more personalized pain therapeutics.Univ Fed Sao Paulo UNIFESP, Diabet Ctr, Endocrinol Div, Escola Paulista Med, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Brazilian Cochrane Ctr, Escola Paulista Med, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Diabet Ctr, Endocrinol Div, Escola Paulista Med, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Brazilian Cochrane Ctr, Escola Paulista Med, Sao Paulo, BrazilWeb of Scienc

The cross-sectional and prospective associations between sleep characteristics and adiposity in toddlers: Results from the GET UP! Study

Background: The associations between sleep characteristics and adiposity in children under three years are not fully understood yet. Objective: The objective of the study is to examine the cross-sectional and prospective associations between sleep characteristics and adiposity in toddlers over a 12-month period. Methods: Participants were 202 toddlers from the GET-UP! Study. Sleep duration, sleep timing, and sleep variability were assessed using 24-hour accelerometry for seven consecutive days. Height and weight were measured, and BMI z scores were calculated. Linear mixed models were performed to examine the cross-sectional and prospective associations between sleep characteristics and adiposity, with adjustments for clustering effects and demographic factors. Results: Total sleep duration was negatively associated with higher adiposity cross-sectionally (B = −0.12; 95% CI: −0.23, −0.01;.033) but not prospectively (B = 0.01; 95% CI: −0.13, 0.10;.843). Nap duration was prospectively associated with higher levels of adiposity (B = 0.41; 95% CI: 0.14, 0.68;.003). Sleep variability and sleep timing were not associated with concurrent or subsequent adiposity. Conclusion: Although sleep duration is an important factor associated with obesity in toddlerhood, the potential effects of different types of sleep duration may vary. While longer total sleep duration may protect children from increasing adiposity, longer nap duration seems to be risk factor. As evidence in this age group is scarce, more research is needed to confirm this finding

Transactional support for adaptive indexing

Adaptive indexing initializes and optimizes indexes incrementally, as a side effect of query processing. The goal is to achieve the benefits of indexes while hiding or minimizing the costs of index creation. However, index-optimizing side effects seem to turn read-only queries into update transactions that might, for example, create lock contention. This paper studies concurrency contr

Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisiae

Background: Resistance to fluconazole, a commonly used azole antifungal, is a challenge for the treatment of fungal infections. Resistance can be mediated by overexpression of ABC transporters, which promote drug efflux that requires ATP hydrolysis. the Pdr5p ABC transporter of Saccharomyces cerevisiae is a well-known model used to study this mechanism of antifungal resistance. the present study investigated the effects of 13 synthetic compounds on Pdr5p.Results: Among the tested compounds, four contained a tellurium-butane group and shared structural similarities that were absent in the other tested compounds: a lateral hydrocarbon chain and an amide group. These four compounds were capable of inhibiting Pdr5p ATPase activity by more than 90%, they demonstrated IC50 values less than 2 M and had an uncompetitive pattern of Pdr5p ATPase activity inhibition. These organotellurides did not demonstrate cytotoxicity against human erythrocytes or S. cerevisiae mutant strains (a strain that overexpress Pdr5p and a null mutant strain) even in concentrations above 100 mu M. When tested at 100 mu M, they could reverse the fluconazole resistance expressed by both the S. cerevisiae mutant strain that overexpress Pdr5p and a clinical isolate of Candida albicans.Conclusions: We have identified four organotellurides that are promising candidates for the reversal of drug resistance mediated by drug efflux pumps. These molecules will act as scaffolds for the development of more efficient and effective efflux pump inhibitors that can be used in combination therapy with available antifungals.Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)University of São Paulo through the NAP-CatSinQ (Research Core in Catalysis and Chemical Synthesis)Univ Fed Rio de Janeiro, CCS, Inst Microbiol Paulo Goes, Dept Microbiol Geral,Lab Bioquim Microbiana, Rio de Janeiro, RJ, BrazilUniv São Paulo, Inst Quim, Dept Quim Fundamental, São Paulo, BrazilInst Fed Educ Ciencia & Tecnol Rio de Janeiro IFR, Rio de Janeiro, RJ, BrazilUniversidade Federal de São Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, São Paulo, BrazilFAPERJ: E-26/111.338/2013FAPESP: 2005/59572-7FAPESP: 2008/55401-1FAPESP: 2010/17228-6FAPESP: 2011/03244-2FAPESP: 2011/11613-8FAPESP: 2012/17093-9CNPq: 470360/2012-7Web of Scienc